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Topoisomerase 2 alpha

WebSep 1, 2015 · The aim of this study was to investigate association between expressions of multidrug resistance protein (MRP) and topoisomerase 2 alpha expression in non-small cell lung cancer (TOP2A) and brain metastasis operatively. The expression of MRP and TOP2A were performed using immunohistochemistry (IHC) staining, and the results were … WebNov 11, 2015 · DNA topoisomerase 2 alpha (TOP2A) is an essential nuclear enzyme, required for resolution of topological stress associated with DNA replication. TOP2A introduces transient double strand breaks (DSB) on DNA in an ATP-dependent fashion to allow changes in DNA topology and eliminate over-winding [1,2]. TOP2A function is crucial …

Identification of novel topoisomerase II alpha inhibitors by virtual ...

WebNov 11, 2015 · DNA topoisomerase 2 alpha (TOP2A) is an essential nuclear enzyme, required for resolution of topological stress associated with DNA replication. TOP2A … WebTarget Information. Topo II alpha plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2 and M-phases in transformed and developmentally regulated normal cellsTopo II alpha is also implicated in drug resistance of tumor ... purple kiss yuki age https://mazzudesign.com

Type II topoisomerase - Wikipedia

WebMay 5, 2014 · cancer agent to target human DNA topoisomerase 2-alpha. Lalit Mohan Nainwal 1, Pratap Parida 2, Aparoo p Das 1 and ParthaSarathi Bairy 1. 1 Department of Pharmaceutical Sciences, ... WebMay 22, 2013 · Background Topoisomerase II alpha (Top 2 A) protein has been shown to be a proliferation marker associated with tumour grade. The current study evaluated the prognostic impact of Top 2 A protein ... There are two subclasses of type II topoisomerases, type IIA and IIB. • Type IIA topoisomerases include the enzymes DNA gyrase, eukaryotic topoisomerase II (topo II), and bacterial topoisomerase IV (topo IV). These enzymes span all domains of life and are essential for function. • Type IIB topoisomerases are structurally and biochemically distinct, and comprise a single family member, topoisomerase VI (topo VI). Type IIB topoisomerases are found in archae… purple kiss yuki wallpaper

Topoisomerase Inhibitors DrugBank Online

Category:Anti-Topoisomerase II alpha antibody [TOP2A/1362] (ab219321)

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Topoisomerase 2 alpha

Topoisomerase II alpha Polyclonal Antibody, FITC - Thermo Fisher Scientific

WebTopoisomerase 2 alpha (TOP2A) is considered to be the molecular target of these drugs. The potential predictive value of TOP2A amplification and overexpression has been extensively studied in breast cancer patients treated with anthracyclines. However, results are not conclusive. In this paper, we review some of the published studies addressing ... WebProtein target information for DNA topoisomerase 2-alpha (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Topoisomerase 2 alpha

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WebMar 21, 2024 · TOP2A (DNA Topoisomerase II Alpha) is a Protein Coding gene. Diseases associated with TOP2A include Malignant Peripheral Nerve Sheath Tumor and … WebApplications. Use a concentration of 1 - 2 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. (Primary incubation for 30 min at RT). Use at an assay dependent concentration. Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 174 kDa.

WebTarget Information. Topo II alpha plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and … WebMay 4, 2001 · Subunit. Homodimer. Interacts with COPS5. Interacts with RECQL5; this stimulates DNA decatenation. ...

WebThe covalently bound topo II was detected in situ by immunofluorescence. Isoform-specific covalent complexes were detected with antisera specific for either the alpha or beta isoform of topo II followed by a fluorescein isothiocyanate-conjugated second antibody. DNA was detected using the fluorescent stain Hoechst 33258. WebTopoisomerase II alpha promotes gallbladder cancer proliferation and metastasis through activating phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin …

WebAll lanes : Anti-Topoisomerase II alpha antibody [EP1102Y] (ab52934) at 1/1000 dilution Lane 1 : HeLa (human cervix adenocarcinoma) whole cell lysate Lane 2 : Jurkat (human acute T cell leukemia) whole cell lysate … purple kiss yuki 出身地Webtopoisomerase (DNA) II alpha nucleus, response to DNA damage stimulus, nucleotide binding, nucleoplasm, ATP binding, protein complex, DNA binding, nucleolus, positive regulation of apoptotic process, protein homodimerization activity, drug binding, metal ion binding, magnesium ion binding, sequence-specific DNA binding, positive regulation of … purple kittyWebThe topo II-alpha index correlates better with the MIB1 index than with the S-phase fraction or mitotic index. The topo II-alpha expression in breast cancer ranges from low (topo II … purple kitty knitting primerWebApr 9, 2024 · The tyrosyl-DNA phosphodiesterase 1 (TDP1) enzyme hydrolyzes the phosphodiester bond between a tyrosine residue and the 3′-phosphate of DNA in the DNA–topoisomerase I (TopI) complex, being involved in different DNA repair pathways. A small TDP1 gene subfamily is present in plants, where TDP1α has been … purple kiss yuki profileWebMar 27, 2024 · Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. The prognostic effect of … purple koala acnhWebTopoisomerase Inhibitors. Compounds that inhibit the activity of DNA TOPOISOMERASES. A cytotoxic drug used as an adjunct for chemotherapy induction in the treatment of refractory childhood acute lymphoblastic leukemia. An antineoplastic enzyme inhibitor used to treat metastatic carcinoma of the colon or rectum. purple kush auto yieldWebEuropium-labeled mouse monoclonal antibody recognizing human DNA Topoisomerase 2-alpha phosphorylated at Thr1342. Sequence motif recognized: DEK(pT)DDE purple koala squishmallow name