WebSep 1, 2015 · The aim of this study was to investigate association between expressions of multidrug resistance protein (MRP) and topoisomerase 2 alpha expression in non-small cell lung cancer (TOP2A) and brain metastasis operatively. The expression of MRP and TOP2A were performed using immunohistochemistry (IHC) staining, and the results were … WebNov 11, 2015 · DNA topoisomerase 2 alpha (TOP2A) is an essential nuclear enzyme, required for resolution of topological stress associated with DNA replication. TOP2A introduces transient double strand breaks (DSB) on DNA in an ATP-dependent fashion to allow changes in DNA topology and eliminate over-winding [1,2]. TOP2A function is crucial …
Identification of novel topoisomerase II alpha inhibitors by virtual ...
WebNov 11, 2015 · DNA topoisomerase 2 alpha (TOP2A) is an essential nuclear enzyme, required for resolution of topological stress associated with DNA replication. TOP2A … WebTarget Information. Topo II alpha plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2 and M-phases in transformed and developmentally regulated normal cellsTopo II alpha is also implicated in drug resistance of tumor ... purple kiss yuki age
Type II topoisomerase - Wikipedia
WebMay 5, 2014 · cancer agent to target human DNA topoisomerase 2-alpha. Lalit Mohan Nainwal 1, Pratap Parida 2, Aparoo p Das 1 and ParthaSarathi Bairy 1. 1 Department of Pharmaceutical Sciences, ... WebMay 22, 2013 · Background Topoisomerase II alpha (Top 2 A) protein has been shown to be a proliferation marker associated with tumour grade. The current study evaluated the prognostic impact of Top 2 A protein ... There are two subclasses of type II topoisomerases, type IIA and IIB. • Type IIA topoisomerases include the enzymes DNA gyrase, eukaryotic topoisomerase II (topo II), and bacterial topoisomerase IV (topo IV). These enzymes span all domains of life and are essential for function. • Type IIB topoisomerases are structurally and biochemically distinct, and comprise a single family member, topoisomerase VI (topo VI). Type IIB topoisomerases are found in archae… purple kiss yuki wallpaper