Myc interactome

Author: aquk

August undefined, 2024

Web5 nov. 2024 · We hypothesized that RROL may shape the protein interacting network of MYC to confer specificity for ACC1 promoter. To this end, we performed mass … Web11 jul. 2024 · We identified 229 c-Myc interacting proteins using HyPR-MS. The c-Myc interactome encompasses RBPs with known or potential roles in transcription, …

MYC as a driver of stochastic chromatin networks: implications for …

Web1 nov. 2024 · resulting in varying signaling outcomes. Hence, the MYC interactome can regulate both proliferation as well as the necessary adaptation to proliferative and meta-bolic stress15,16. For example, in glucose dependent tumor entities, such as triple negative breast cancer or malignant melanoma, MYC and MondoA behave antago-nistically17,18. Web20 nov. 2024 · Along this line, SNVs affecting the C-terminal HLH domain are predicted to positively affect MYCN interactome in these cases, in contrast to MYC, which is overall … safety 1 pty ltd

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis

WebSummary. Transforming members of the MYC family ( MYC, MYCL1, and MYCN) encode transcription factors containing six highly conserved regions, termed MYC homology boxes (MBs). By conducting proteomic profiling … Webc-MYC controls global gene expression and regulates cell proliferation, cell differentiation, cell cycle, metabolism and apoptosis. According to some estimates, MYC is dysregulated … Web15 dec. 2010 · A significant number of c-Myc interacting proteins have already been defined, but it is widely believed that the c-Myc interactome is vastly larger than currently … safety 1st 3 in 1 nursery thermometer

An Overview of MYC and Its Interactome - CSHL P

IJMS Free Full-Text Therapeutic Inhibition of Myc in Cancer

Web6 dec. 2024 · MYC amplification is an independent prognostic factor for the most aggressive subgroup (Group 3) of pediatric medulloblastoma (G3 MB). Here, the authors highlight … Web6 dec. 2024 · MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis. Kalkat M, Resetca D, ... Transforming Members Of … safety 1 holcimWeb6 dec. 2024 · MYC contains six highly conserved regions termed MYC homology boxes (MBs), present in all three transforming members of the MYC family: c-, N-, and L-MYC … the world of cecil taylor

"Web23 nov. 2024 · MYC multimers accumulate on chromatin immediately adjacent to stalled replication forks and surround FANCD2, ATR and BRCA1 proteins, which are located at … " - Myc interactome

Myc interactome

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Web29 aug. 2024 · The c-MYC (MYC) oncoprotein is deregulated in over 50% of cancers, yet regulatory mechanisms controlling MYC remain unclear. To this end, we interrogated the … Web5 mei 2024 · Previous proteomic studies have shown that MYC and the closely related MYCN protein interact with several Pol II-associated protein complexes. Recent systemic interaction studies using BioID indicate that MYC is in proximity to 336 proteins ( …

Did you know?

Web1 apr. 2014 · Request PDF An Overview of MYC and Its Interactome (Vol 4, a014357, 2014) This review is intended to provide a broad outline of the biological and molecular … Web1 mei 2015 · It is appreciated that Myc possesses a large interactome, yet the functional relevance of many interactors remains unknown. Here, we discuss future research …

Web21 feb. 2024 · The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics. Thomas O'Loughlin. ... pM or myc-BirA* pLXIN2 … Web29 jun. 2024 · The ongoing characterization of the MYC protein interactome will not only help to define MYC function mechanistically but should also identify new therapeutic …

WebAn Overview of MYC and Its Interactome. This corrects the article "An Overview of MYC and Its Interactome" in volume 4, a014357. In the original version of this article, one of … http://perspectivesinmedicine.cshlp.org/content/4/1/a014357.full

Web29 jan. 2024 · Enzyme-catalyzed proximity labeling (PL) combined with mass spectrometry (MS) has emerged as a revolutionary approach to reveal the protein-protein interaction networks, dissect complex biological processes, and characterize the subcellular proteome in a more physiological setting than before.

WebMYC multimerization is triggered in a HUWE16 and ubiquitylation-dependent manner. At active promoters, MYC multimers block antisense transcription and stabilize FANCD2 … the world of cheeseWeb11 jul. 2024 · We analyzed c-Myc mRNA protein interactors in vivo using the HyPR-MS method to capture the crosslinked mRNA by hybridization and then analyzed the bound … safety 1st 4 pack washclothsWebWe present a view of MYC as a sensor that integrates multiple cellular signals to mediate a broad transcriptional response controlling many aspects of cell behavior. We also … safety 1st 3 in 1 thermometer the world of ch pzWeb7 sep. 2024 · Multimerization is accompanied by a global change in the MYC interactome towards proteins involved in transcription termination and RNA processing. MYC … safety 1st 6 pack side by side cabinet lockWeb6 dec. 2014 · MLXIP (MAX like protein X interacting protein, also known as MondoA) is a metabolic stress sensor and a proglycolytic transcription factor potentially involved in … safety 1st 3 in 1 car seat reviewsWeb30 jan. 2024 · MYC oncoprotein deregulation is a common catastrophic event in human cancer and limiting its activity restrains tumor development and maintenance, as clearly … the world of children