Cinnamic acid inhibition cancer cells

Author: jlwm

August undefined, 2024

WebNov 1, 2024 · Thus, inhibition of CBR1 can increase the therapeutic effect of DOX. In the present study, we used a group of new synthetized cinnamic acid (CA) derivatives to … WebApr 12, 2024 · Naproxen is widely used for anti-inflammatory treatment but it can lead to serious side effects. To improve the anti-inflammatory activity and safety, a novel naproxen derivative containing cinnamic acid (NDC) was synthesized and used in combination with resveratrol. The results showed that the combination of NDC and resveratrol at different …

PLGA nanoparticles in loading trans-cinnamic acid IJN

WebCA can inhibit the growth of leukaemia cells by inducing cell apoptosis and significantly affected the cell cycle after 48 h treatment, resulting in increased G0/G1 phase and extension of thecell cycle in the tumour cells. This study aims to investigate the effect and mechanism of action of cinnamic acid (CA) on the proliferation and apoptosis of … WebBackground/aim: Breast cancer is the second leading cause of cancer-related deaths in US, which necessitates constant research for medications with minimal adverse effects. … css full page height

Cytotoxic and Immunomodulatory Potential Activity of

WebApr 1, 2024 · We synthetized seventeen cinnamates derived from trans -cinnamic acid. • The Steglich esterification reaction was the main step involved in their synthesis. • The most effective compound 3q reduced the melanoma cell viability. • Compound 3q caused cell cycle arrest and apoptosis in B16-F10 cells. • WebMar 25, 2015 · Although one of the best characterized inhibitors, α-cyano-4-hydroxycinnamic acid (α-CCA), possesses a 10-fold selectivity for MCT1 compared to other subtypes (Figure 1) [22], it also shows ... Webimportant in cancer treatment. Cinnamic acid (CA), a phenylalanine deamination product in plant tissue, is the main active ingredient extracted from food-flavouring ... suggesting … css full page

Cinnamic acid: a natural product with potential use in cancer

Cinnamic Acid Derivatives as Inhibitors of Oncogenic Protein …

WebNov 30, 2024 · However, treating the colon cancer cells with DHCA for 48h showed much better HDAC inhibitory effect (80% and 77% HDAC inhibition, respectively in HCT116 … Webp-Coumaric acid (pCA) is a hydroxycinnamic acid derivative commonly found in many natural products that has been extensively studied for its anticancer activity in multiple … css full page background imageWebJul 28, 1995 · We now show that cinnamic acid induces cytostasis and a reversal of malignant properties of human tumor cells in vitro. The concentration causing a 50% … earley flooring vincennes indiana

"WebP-Coumaric acid, an abundant isomer of cin- namic acid, inhibits the colon cancer cell lines by in- creasing the ROS levels, decreasing the mitochondrial membrane potential and inhibiting the cell cycle at sub G1 phase [52]. Esters of cinnamic acids are more potent when compared to the hydroxylated or the methoxylated versions [40]. " - Cinnamic acid inhibition cancer cells

Cinnamic acid inhibition cancer cells

Induction of colon and cervical cancer cell death by cinnamic acid ...

WebDec 19, 2024 · Inflammation and oxidative stress are involved in cardiovascular diseases. Nitrogen monoxide participates in the regulation of endothelial processes. Thus, derivatives of classic nonsteroidal anti-inflammatory drugs (NSAIDs), trolox or cinnamic acids esterified with 2-(nitrooxy)ethanol were designed and studied. It was found that the nitrogen … WebMar 23, 2016 · For the inhibition of cancer cell proliferation, the concentration of tCA reaching mM levels was required; however, the study data verified that tCA interfered in histone acetylation via inhibiting HDAC, leading to cancer cell cytotoxicity. In addition, the therapeutic efficacy of tCA has been confirmed. ... Cinnamic acid induces apoptotic cell ...

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WebSep 25, 2013 · Interestingly, cinnamic acid also exhibits anti-cancer activity in the cancer stem cells. Huang et al. (2012)examined the effect of cinnamic acid in lung cancer stem cells.... WebApr 10, 2024 · Cervical carcinoma is one of the most common cancers among women globally. Histone deacetylase inhibitors (HDACIs) constitute anticancer drugs that, by increasing the histone acetylation level in various cell types, induce differentiation, cell cycle arrest, and apoptosis. The aim of the current review is to study the role of HDACIs in the …

Webp-Coumaric acid (pCA) is a hydroxycinnamic acid derivative commonly found in many natural products that has been extensively studied for its anticancer activity in multiple cell lines.In this report we investigated the effects of this phytochemical as adjuvant therapy to treat glioblastoma, an infaust brain tumour characterized by the acquired or innate … WebThe potential of cinnamic acid as an anti-inflammatory and anti-cancer agent has been studied previously. In our investigation, novel bio-isosters of cinnamyl sulfonamide hydroxamate were synthesized, characterized and confirmed for their structure and evaluated for cytotoxicity. ... -2 and -3 showed cell-growth inhibition in 6 human cancer ...

WebThe effect of the inhibitors on cell cycle distribution was measured by propidium iodide staining. Results: The combination treatment of ethacrynic acid and cinnamic acid … WebOct 21, 2024 · Incubation of human colorectal cancer cells in the presence of cinnamic acid at concentration higher than 10 mM resulted in reduced cell viability (IC50 13.6 mM). ... The mechanism is attributed to the lower expression of some drug resistance proteins, inhibition of cell proliferation, and promotion of apoptosis (Lu et al. 2024).

WebApr 12, 2024 · At 1.5 µM cinnamic acid addition, the biomass level and chrysin production demonstrated a sharp decrease of 1.62 g/L and 3.80 mg/L, respectively. Cinnamic acid is a key metabolite that regulates several metabolic pathways in microbes. In plants, it acts as an allelochemical that influences seed germination and root growth.

WebJan 3, 2024 · Treatment with Cinnamic acid (CINN) of various tumor cells of epithelial and neuroectodermal origin result in dose-dependent growth inhibition following a 3-day exposure. The inhibitory concentrations causing a 50% reduction in tumor-cell proliferation (IC50) are between 1.2 to 4.5 mM. css full pdfWebCinnamic acid belongs to phenolic-acid class of polyphenols, one of the most abundant plant secondary metabolites. These substances are widely studied because of plethora … css full-screenWebMay 23, 2013 · The growth inhibition was probably associated with DNA damage leading to DNA synthesis inhibition, as shown by BrdU incorporation assay, induction of nuclear aberrations and then apoptosis. The frequency of cell death caused by cinnamic acid was higher in HT-144 cells. earley fireworks css full resolution backgroundWebFeb 28, 2024 · Previous studies have shown that intensive macropinocytosis occurs in cancer cells and neutral red (NR) is noted for its capability to enter into the cell … css full screen fog effectWebFeb 26, 2024 · Propolis extract or components was reported to be cytotoxic to several cancer cells [20, 21] and to induce autophagy in breast cancer cells [9].In order to elucidate whether and what kind of propolis components exhibits the above actions on prostate cancer CWR22Rv1 cells, the cytotoxic effects of eight cinnamic acid … css full page background cssWebNov 21, 2016 · A group of compounds related to cinnamic acid (e.g., caffeic acid and ferulic acid) have been identified as potential ... CA promotes cancer cell death through alterations in mitochondrial membrane potential and lipid ... Mueller-Klieser W, Vaupel P. Lactate-induced inhibition of tumor cell proliferation. Int J Radiat Oncol Biol Phys. … css full page width