Chronic-plus-single-binge ethanol feeding
WebMar 9, 2024 · Experimental Approach. In vivo models of acute and chronic alcoholic hepatosteatosis were established by intragastrically administered ethanol or using chronic plus binge ethanol feeding of Lieber‐DeCarli liquid diet to male C57BL/6 mice.In vitro, HepG2 cells were treated with ethanol. RAW 264.7 macrophages and murine bone … WebThis protocol for chronic-plus-single-binge ethanol feeding synergistically induces liver injury, inflammation and fatty liver, which mimics acute-on-chronic alcoholic liver injury in patients. This feeding protocol can also be extended to chronic feeding for longer periods of time up to 8 weeks plus single or multiple binges.
Chronic-plus-single-binge ethanol feeding
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WebMar 26, 2013 · Alone, ethanol feeding for 10 days (chronic) or a single gavage of ethanol (binge) induced only a mild elevation of serum ALT and AST in female C57BL/6J mice (Fig. 1 A). In contrast, as expected, … WebJul 16, 2010 · Chronic-binge induced the highest levels of serum ALT and AST compared to 4-week, 10-day ethanol feeding, or single ethanol gavage alone (Fig. 1F). The detailed comparison of liver injury between …
WebFeb 28, 2013 · This protocol for chronic-plus-single-binge ethanol feeding synergistically induces liver injury, inflammation and fatty liver, which mimics acute-on-chronic … WebJun 1, 2016 · Collectively, chronic plus binge EtOH feeding in mice leads to alcohol-induced cardiomyopathies (National Institute on Alcohol Abuse and Alcoholism models) …
WebMay 25, 2016 · As shown in Table 1, there was no significant difference in final body weight between four groups, whereas the chronic ethanol feeding plus a single binge alcohol feeding... WebThe C57BL/6 J mice were subjected to a chronic plus a single binge ethanol feeding protocol proposed by the National Institute on Alcohol Abuse and Alcoholism [Citation 17]. In brief, these mice were first given the Lieber-DeCarli liquid control diet (F1259SP, Bioserv, Flemington, NJ, USA) for 5 days and further pair-fed with the Lieber-DeCarli ...
WebFeb 28, 2013 · This protocol for chronic-plus-single-binge ethanol feeding synergistically induces liver injury, inflammation and fatty liver, which mimics acute-on-chronic …
WebThis chronic plus single-binge ethanol–feeding protocol induces liver injury, inflammation, and fatty liver synergistically, which mimics acute-on-chronic alcohol liver … normalquality是什么意思WebApr 22, 2016 · Chronic plus binge ethanol feeding induces myocardial oxidative stress, mitochondrial and cardiovascular dysfunction, and steatosis. ... how to remove scratches on lensesWebChronic-plus-binge ethanol feeding of mice, which mimics the drinking pattern of patients with AH, produced severe ASH and mild fibrosis. … normal qtc men vs womenWebSep 24, 2024 · The impact of mangiferin on ethanol-induced liver injury and the probable underlying molecular mechanism has not been sufficiently addressed. In the present study, mice were subjected to a chronic plus … normal qtc interval rangeWebJul 1, 2024 · The chronic and binge ethanol feeding protocol comprises three stages. Stage 1. Acclimation to liquid diet feeding. Mice are fed ad libitum with the control … normal rabbit hrWebJul 1, 2024 · Long-term (8-week) chronic plus single or multiple (twice a week) binge ethanol feeding induce more severe steatohepatitis and mild fibrosis. This clinically relevant, easy-to-perform... normal rabbit teeth picturesWebHerein, alcoholic fatty liver induced by chronic-plus-single-binge ethanol feeding to male C57BL/6J mice was manifested by hampering autophagosomes formation with lipid droplets and fusion with lysosomes compared with the normal control, which was normalized partially by quercetin. The GST-RILP pulldown assay of Rab7 indicated an improved GTP ... how to remove scratches on leather chair