Chromosome substitution strains

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August undefined, 2024

WebChromosome substitution strains (CSSs) are based on a different paradigm that deal with the signal-noise problem in a novel way ( 20 ). Each CSSs is an inbred strain that differs from the host strain by a single intact and homozygous chromosome on a defined and uniform genetic background. WebChromosome substitution strains (CSS) were originally obtained as a gift from Dr. Joseph Nadeau (Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106). Each CSS is a homozygous inbred strain that is C57BL/6J with one chromosome pair from A/J.

Chromosome Substitution Strain - an overview

WebDec 16, 2008 · Chromosome substitution strains (CSSs) enable statistically powerful studies based on testing engineered inbred strains that have single, unique, and … WebFeb 3, 2010 · Discovery of genes that confer resistance to diseases such as diet-induced obesity could have tremendous therapeutic impact. We previously demonstrated that the C57BL/6J-ChrA/J/NaJ panel of chromosome substitution strains (CSSs) is a unique model for studying resistance to diet-induced obesity. In the present study, three … how to go incognito on facebook

Genetic Dissection of Complex Traits with Chromosome …

WebChromosome substitution strains (CSSs) are based on a different paradigm that deal with the signal-noise problem in a novel way . Each CSSs is an inbred strain that differs from … WebApr 16, 2004 · Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, physiological, and behavioral processes. Here, we report the construction of a complete CSS panel for a vertebrate species. WebA chromosome substitution strain (CSS) or consomic strain is an inbred strain in which a single chromosome from a donor strain replaces the corresponding chromosome in … johnston area gastroenterology

Genetic architecture of complex traits: Large phenotypic effects …

WebNov 4, 2024 · Chromosome substitution strains C57BL/6J-Chr# A /J/NaJ (20, 23), hereafter referred to as CSS, for all chromosomes except Y and the mitochondrial genome, were purchased from the Jackson Laboratory (JAX, Bar Harbor, Maine) and imported to the University of Colorado Boulder. The JAX strain IDs for the CSS are continuous from … WebRecombinant inbred (RI) and chromosome substitution (CS) strain panels Many common inherited human diseases — such as diabetes, cardiovascular disease, obesity, … johnston architects houstonWebA chromosome substitution strain (CSS) is an inbred strain in which one chromosome has been substituted from a different inbred strain by repeated backcrossing. A complete CSS set has one strain representing each chromosome against a uniform background, thus allowing genome-wide scans to be carried out for quantitative trait loci (QTLs) … johnston architects seattle wa

"WebSep 29, 2024 · Analyzing metabolic traits and gene expression levels in the offspring of a series of crosses between mouse chromosome substitution strains demonstrated that inter-chromosomal epistasis was a dominant feature of these complex traits. Epistasis typically accounted for a larger proportion of the heritable effects than those due solely to … " - Chromosome substitution strains

Chromosome substitution strains

WebMay 23, 2024 · chromosome substitution The replacement of one or more chromosomes by others (totally or partially homologous) from another source (either a different strain … WebChromosome substitution strains QTL mapping can be accelerated using chromosome substitution strains (CSSs), which enable the first two steps above to be omitted. We …

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WebJun 29, 2016 · Selecting chromosome substitution strains (CSSs, also called consomic strains/lines) used in the search for quantitative trait loci (QTLs) consistently requires the identification of the respective phenotypic trait of interest and is simply based on a significant difference between a consomic and host strain. However, statistical significance as … WebJan 23, 2024 · Chromosome substitution strains, also known as consomic strains, provide a simple model for exploring genetic influences. They consist of a panel of strains where one chromosome of a host strain is replaced by a homologous chromosome of a donor strain ( Matin et al., 1999; Singer et al., 2004; Ishii et al., 2011 ).

WebGenetic crosses and chromosome substitution experiments conclusively showed that the expression of both genes (located on the 2R chromosome) is repressed by factors on the third chromosome of the insecticide-susceptible 91C and rosy 506 strains. In contrast, the third chromosome of the MHIII-D23 and 91R strains carries a loss-of-function ... WebJul 8, 2003 · A chromosome substitution strain (CSS) is an inbred strain in which one chromosome has been substi-tuted from a different inbred strain by repeated backcrossing. A complete CSS set has one strain representing each chromosome against a uniform background, thus allowing genome-wide scans to be carried out for …

WebGenetic resistance to diet-induced obesity in chromosome substitution strains of mice.pdf. 2011-11-03 ... WebChromosome substitution strains QTL mapping can be accelerated using chromosome substitution strains (CSSs), which enable the first two steps above to be omitted. We propose replacing the name...

WebApr 16, 2004 · Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, …

WebMay 23, 2024 · chromosome substitution The replacement of one or more chromosomes by others (totally or partially homologous) from another source (either a different strain of the same species or a related species that will permit hybridization) by a suitable crossing programme. A Dictionary of Zoology MICHAEL ALLABY johnston archiveWebSep 8, 2012 · Chromosome substitution strains (CSSs) are important in this resource portfolio because of their demonstrated use for gene discovery, genetic and epigenetic studies, functional characterizations, and systems analysis. CSSs are made by replacing a single chromosome in a host strain with the corresponding chromosome from a donor … how to go incognito on laptop googleWebChromosome substitution strains (CSSs) are a powerful complement to existing resources for studying multigenic traits. By partitioning the genome into a panel of … johnston architects pllcWebFeb 1, 2006 · (3) Chromosome substitution strains (CSS) Chromosome substitution strains (CSS) are mice strains with one single chromosome replaced by the corresponding chromosome from a donor strain... how to go incognito on iphone 6WebGenetic crosses and chromosome substitution experiments conclusively showed that the expression of both genes (located on the 2R chromosome) is repressed by factors on the third chromosome of the insecticide-susceptible 91C and rosy506 strains. how to go incognito on my computer how to go incognito on ios 15WebMar 28, 2024 · 5.3 Chromosome Substitution or Consomic Strains 5.3.1 Consomic Strains 5.4 Segregating Inbred Strains 5.5 Conplastic Strains 6. Outbreds and Closed Colonies 6.1 Outbreds 6.2 Closed Colonies 7. ES cell lines and iPS cell lines 8. References 1. Introduction Mice and rats used in the laboratory derive from a variety of sources. how to go incognito on kindle